Wuhan Fantaike pharmaceutical Technology Co., Ltd.

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TEL : 86-027-87742566 / FAX : -- / Mobile : --
No. 2159 JieFang Road,Erqi Street, JianAn District, Hubei Provience, Wuhan China [CN]
Contact Name : Sara

Main Products

API , API , API , API , API

Business Type

Manufacturer

Product

GW501516

Posting date : Jul 10, 2017

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Membership

Free Member Scince Jan 03, 2017

FOB Price

negotiation

Min. Order Quantity

20g

Supply Abillity

enough

Port

shanghai

Payment Terms

T/T

Package

Foil bag

Keyword :

GW501516

Category

CHEMICAL | Inorganic chemic | Fluorine chlorin | Chlorine

Contact

Sara

Product Detail

Company Info

Quick Detail

Place of Origin

China [CN]

Brand Name

fantike

HS-CODE

2801-10

Package & Delivery Lead Time

Package

Foil bag

Detailed Description

Name: GW501516

CAS No.: 317318-70-0

Appearance: white powder

Purity : ≥ 99%

Molecular formula: C21H18F3NO3S2

Molecular weight: 453.50

Detail:

GW501516 also known as GW-501,516, GW1516 and GSK-516.It is a selective agonist (activator) of the PPARδ receptor. It was entered into clinical development as a drug candidate for metabolic diseases and cardiovascular diseases.

GW501516 is a synthetic ligand of PPARδ and belongs to the phenoxyacetic acid derivative. After binding to GW501516, activated PPARδ forms a heterodimer with 9-cis retinoid receptor (RXR) And then identify the peroxisome proliferator response element (PPRE) upstream of the target gene promoter to regulate gene transcription, translation and biological effects downstream of the target gene.

GW501516 inhibits apoptosis of ox-LDL or high glucose-induced HUVECs and attenuates the inhibitory effect of ox-LDL or high glucose on HU-VECs activity.